![]() ![]() Therefore, it is possible that vitamin C supplements can treat the symptoms of vitamin C deficiency, including fatigue, and relieve fatigue through neuroprotective and vasoprotective effects due to its antioxidant and anti-inflammatory properties. Fatigue, pain, cognitive disorders, and depression-like symptoms are known symptoms of a vitamin C deficiency. Vitamin C deficiency causes clinically related diseases. Water-soluble vitamins are one of the body’s most important antioxidants and are involved as a co-factor in more than 150 metabolic functions. Physical fatigue is tightly associated with maintenance of the balance between nutrition and energy metabolism. Therefore, one of the ways to suppress fatigue involves the elimination or inhibition of the production of fatigue-related metabolites during exercise. Some reports have suggested that the combination of supplementation with essential nutrients and aerobic exercise is an effective approach to preventing CFS. Nevertheless, there is no effective treatment to prevent CFS. There is no specific treatment except lifestyle change, and this lack of relief leads to chronic impairment of quality of life, CFS is associated with concentration deficiency, memory loss, muscle aches, and sleep deprivation and the global incidence of CFS and its prevalence have been steadily rising. Chronic fatigue can cause serious health problems, and the lack of control over fatigue is emerging as an important issue. Conclusions: These results suggest that vitamin C and TR have anti-fatigue activities in mice, with vitamin C providing a stronger effect.Ĭhronic fatigue syndrome (CFS) is a clinical condition defined by persistent fatigue lasting more than 6 months that is not amended by rest. Moreover, TG (C100, C200, T200), LDH (C200), lactic acid (C100) and MDA (C50, C100, C200) levels were inhibited by vitamin C and TR. ![]() Results: Compared with the control group, C100, C200, and T50 showed a tendency to decrease mobility in FST. Materials and Methods: Vitamin C, TR or their combination were orally administrated to mice once daily for 15 days, and then metabolic activities such as blood glucose, triglyceride (TG), lactate, and lactate dehydrogenase (LDH) as well as antioxidant activities such as malondialdehyde (MDA) and superoxide dismutase (SOD) were determined (evaluated) after forced swimming test (FST). Our study was designed to evaluate the anti-fatigue activities of vitamin C and TR in an animal test for fatigue and to compare the activities between vitamin C and TR. However, the mechanism of the anti-fatigue effects of vitamin C and TR is still unclear. ![]() Vitamin C and taurine (TR) are well known as active components for fatigue recovery. ![]()
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